Doctor Strange (odds of dying: 250 to 1)
Doctor Strange (Benedict Cumberbatch) has only had one solo film and it was successful enough to earn a sequel. Doctor Strange may not have been a breakout sensation quite like Guardians of the Galaxy, but it outperformed Ant-Man, another debut solo film that got a sequel.
That potential Doctor Strange sequel, however, still has not been officially announced. The most likely reason is Marvel Studios’ general stance of announcing as little as possible about what comes after Avengers 4, but there is a slight chance that Stephen Strange won’t be around for a sequel. He is going to be right in the thick of the action, so even though he has the ability to keep himself safe from many threats, he may also choose to sacrifice himself to save others.
War Machine (odds of dying: 200 to 1)
A name character who doesn’t lead his own movies sounds like an easy target, but Col. James Rhodes (Don Cheadle) has a better than good chance of getting out alive. He’s already taken the biggest hit of Phase 3 with his crash landing in Captain America: Civil War, so it might feel a little too repetitive (and cruel) to go after him again in his very next cinematic outing. His close friendship with Tony Stark is really the only thing keeping him from being completely out of danger.
Drax (odds of dying: 150 to 1)
If a member of the Guardians of the Galaxy is going to die, it’s going to be Drax. We already know from the first Guardians of the Galaxy that he is set on revenge against Thanos. If Drax really goes toe-to-toe with The Mad Titan, it could wind up like Drax’s first fight with Ronan (Lee Pace), except this time, Drax may not be left alive.
The Guardians having to deal with the loss of one major team member would be an interesting starting point for GotG Vol. 3, but the odds of Drax dying are still fairly long since James Gunn likely had the power of veto on killing Guardians and would have exercised it for the core team. Gunn would likely insist on his trilogy feeling as self-contained as possible and it would be hard to achieve that with a main team member disappearing between the second and third films.